Opportunities and challenges for T cell-based influenza vaccines

TR Mosmann, AJ McMichael, A LeVert… - Nature Reviews …, 2024 - nature.com
… of any influenza vaccine is measured against high levels of pre-… of influenza virus antigens
(five epitopes from haemagglutinin, … blood may exist in equilibrium with the lymphoid T FH cell

[PDF][PDF] Influenza vaccine format mediates distinct cellular and antibody responses in human immune organoids

JM Kastenschmidt, S Sureshchandra, A Jain… - Immunity, 2023 - cell.com
… understand how antigen-specific B and T cells were activated … inactivated influenza vaccine
(IIV) is a 1:40 hemagglutination … disparate outcomes is that high levels of antibodies at the …

Baseline innate and T cell populations are correlates of protection against symptomatic influenza virus infection independent of serology

…, TL Wilson, DG St. James, SS Menon, T Wood… - Nature …, 2023 - nature.com
… against influenza viruses is the substantial degree of baseline immune variation that exists
across … cases, identified by seroconversion (fourfold or greater increase in hemagglutination

… , polyfunctional CD4 T cell response in the murine lung specific for a highly conserved influenza virus antigen that is sufficient to mediate protection from influenza …

SA Nelson, T Dileepan, A Rasley, MK Jenkins… - Journal of …, 2021 - Am Soc Microbiol
… immunodominant CD4 T cell epitopes across hemagglutinin (… , but no significant differences
existed between groups (Fig. 4G … Whereas CD4 T cells uniformly expressed high levels of …

Antigenspecific and cross‐reactive T cells in protection and disease

N Jiang, M Malone, S Chizari - Immunological reviews, 2023 - Wiley Online Library
… Thus, about 2.6 × 107 non- naïve T cells exist in secondary … high- grade glioma with high
levels of activated CD8+ Tcell … Cytotoxic T lymphocytes recognize influenza haemagglutinin

[HTML][HTML] Cellular and Molecular Immunity to Influenza Viruses and Vaccines

J Kasten-Jolly, DA Lawrence - Vaccines, 2024 - mdpi.com
… clones exists between anti-idiotypic antibodies and T cell receptors. … B cells and conserved
regions within the hemagglutinin … strain and showed a high degree of somatic hypermutation, …

[HTML][HTML] Tissue resident memory T cells in the respiratory tract

MZM Zheng, LM Wakim - Mucosal immunology, 2022 - Elsevier
T cells expressed greater levels of T-bet compared with adult … + T cell-specific for influenza
hemagglutinin demonstrated … they did not equilibrate among immunized parabiotic mice and …

[HTML][HTML] Pre-existing CD4 T cell help boosts antibody responses but has limited impact on germinal center, antigen-specific B cell frequencies after influenza infection

DF Besavilla, L Reusch, J Enriquez, K Schön… - Frontiers in …, 2023 - frontiersin.org
… ) CD4 + T cells on the magnitude and quality of hemagglutinin (… mainly confirmatory, given
the large extent of pre-existing … , no data exist on which antigen-specific cells are specifically

[HTML][HTML] The link between circulating follicular helper T cells and autoimmunity

LSK Walker - Nature Reviews Immunology, 2022 - nature.com
… These FOXP3 + T FH cells express high levels of CTLA4 and … -2 that a variety of mechanisms
exists to subvert this inhibition. … obtain help from haemagglutinin-specific T cells to produce …

Measures of epitope binding degeneracy from T cell receptor repertoires

A Mayer, CG Callan Jr - Proceedings of the National …, 2023 - National Acad Sciences
… by the overlap between their human leukocyte antigen (HLA) types; … in mixtures exists. For
example, no equivalent formula … to quantify the functional diversity of a T cell compartment, as …